Bious Labs TechnologyWe are startup of Kaunas University of Technology (est 2018), with the background in process engineering. Our primary scope is converting recent advances in additive manufacturing, electrospinning, and biocompatible matrixes from scientific scale to industrial scale applications. Our areas of interest cover biomed and cleantech sectors, but expanding to many challenges from variety of industries.
We are not just R&D company, although we do make our own machines from scratch. We are PhDs in chemistry and technology thus specifically underpinning the processes for your needs and applications. We spent 10 recent years researching and applying electrospinning to multiple solutions, thus having unique expertise that goes beyond simple fibre fabrication.
We have close cooperation with the University eco-system in Lithuania, including Kaunas University of Technology, Lithuanian University of Health Sciences, Centre of Innovative Medicine and others. This cooperation allows in depth testing and characterization of the developed technology and matrixes, including microscopy, spectroscopy, mechanical tests, and in vitro tests.
Our staff comprised of scientists having deep expertise in grant proposal development and project management. As a company, we have implemented or implementing 5 development projects, with the total funding approaching 0.5 MEur.
Project: Environment friendly air filters from biobased polymers. project No. 01.2.2-MITA-K-702-06-0009) from the Central Project Management Agency of Lithuania. The goal of the project is to create environmentally friendly air filter for ventilation systems. The filter material is fabricated of the of biological origin components and is characterized by high technical properties, but has a lower impact on the environment, especially the life cycle of raw materials extraction and operation in phase. Project duration – August 2023 – July 2024.
Project: Innovative Next-Generation Tissue Engineering Scaffold for In Vitro Studies based on Gradient Interconnecting Pores (No. P-TPP-23-054, Led by Lithuanian University of Health Sciences, funded by the Research Council of Lithuania). The aim of this project is to develop an original scaffold for in vitro cell studies, which will feature interconnected pores with a gradient structure. The field of tissue engineering has been extensively studied in recent years, with the goal of developing new personalized treatment methods, medicinal preparations, and gathering new scientific knowledge about the mechanisms of disease development. In vitro cell research is promoted as part of the 3R strategy, and superior 3D in vitro models are constantly being sought and developed. This project aims to develop a 3D scaffold that has two unique features – a gradient structure of communicating pores, similar to natural tissues, and double-layered nanofibers with coaxially encapsulated bioactive substances. The gradient structure of the scaffold aims to replicate the natural extracellular structure in organisms, providing structural support, biomechanical stimuli, and bioactive cell anchors. The biomechanical stimuli trigger a cascade of signaling pathways within cells. The unique scaffold will be produced using a newly developed 3D fiber printing technology that combines the manufacturing methods of nano and microfibers. The hybrid scaffold with interconnected gradient pores created during this project will have unique properties and be suitable for use in a wide range of in vitro studies, including 3D cell culture models, tissue formation, and cell migration/infiltration studies. Project duration – August 2023 – October 2024.
Project: 3D constructs for cell cultivation for in vitro investigations (No. TPP-04-077, Led by Lithuanian University of Health Sciences, funded by the Agency for Science, Innovation and Technology). Project aims at the commercialization of porous structures obtained by additive manufacturing – 3D fibre printing – for cultivation of specific cells in vitro and to optimize their composition for toxicity studies on substances. Project was completed in November of 2022.
Contracted manufacturing: Fabrication and production of microfibrous substrate (Kaunas University of Technology), 2022.02-006-K-0112Tis
Project: Commercialization of cosmetic preparations with bioactive substances in hydrocoloidal matrixes. Project No. 01.2.2-MITA-K-702-06-0009) from the Agency for Science, Innovation and Technology (MITA) for the commercialization of therapeutic cosmetic products with bioactive substances in hydrocolloid matrixes utilising technological opportunities provided by 3D fibre printing technology. Project has been completed in October of 2021.
Contracted manufacturing: Selection of bioactive material and characterization of membrane (Lithuanian University of Health Sciences), 2021.
Project: Development and prototyping of 3D nano/micro fiber printing technology (project No. 31V-3V3-1350, funded by the Agency for Science, Innovation and Technology (MITA). During the project, a 3D fiber printer was designed and manufactured, which includes the integration of two processes – 3D printing melt deposition modeling and melt electrospinning methods. The testing of the layout technology was carried out in order to determine the possible limits of the main technological parameters and their dependencies on the composition and properties of the medical and pharmaceutical matrices/matrices of the final product. Project was completed in September, 2020.